Proteomics

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Proteomic analysis of exosome-like vesicles isolated from saliva of the tick Haemaphysalis longicornis


ABSTRACT: In this study, extracellular vesicles were isolated from tick saliva and were analyzed for the presence of proteins. LC-MS/MS identified proteins within tick-derived EVs which may be used by tick in modulating host responses.

ORGANISM(S): Haemaphysalis Longicornis

SUBMITTER: Jinlin Zhou  

PROVIDER: PXD018853 | iProX | Tue Apr 28 00:00:00 BST 2020

REPOSITORIES: iProX

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Publications

Proteomic Analysis of Exosome-Like Vesicles Isolated From Saliva of the Tick <i>Haemaphysalis longicornis</i>.

Nawaz Mohsin M   Malik Muhammad Irfan MI   Zhang Houshuang H   Hassan Ibrahim A IA   Cao Jie J   Zhou Yongzhi Y   Hameed Mudassar M   Hussain Kuthu Zulfiqar Z   Zhou Jinlin J  

Frontiers in cellular and infection microbiology 20201022


Extracellular vesicles (EVs), are considered as vehicles of cellular communication. Parasites usually release EVs in their excretory-secretory products to modulate host environment. However, little is known about the secretion of EVs by ticks. In this study, we show for the first time that the tick <i>Haemaphysalis longicornis</i> secretes EVs in saliva that resembles exosomes. EVs were purified from pilocarpine induced saliva of partially engorged <i>H. longicornis</i> ticks. Electron microscop  ...[more]

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