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Omics score: 3

Cross-Linking Mass Spectrometry (CXMS) of human pre-60S ribosomal particles

ABSTRACT: Cross-Linking Mass Spectrometry (CXMS) analysis of human pre-60S ribosomal particles.

ORGANISM(S): Homo Sapiens

SUBMITTER: Meng-Qiu Dong

PROVIDER: PXD019025 | iProX | Thu May 07 00:00:00 BST 2020

REPOSITORIES: iProX

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Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

Liang Xiaomeng X Zuo Mei-Qing MQ Zhang Yunyang Y Li Ningning N Ma Chengying C Dong Meng-Qiu MQ Gao Ning N

Nature communications 20200715 1

Ribosome biogenesis is an elaborate and energetically expensive program that involve two hundred protein factors in eukaryotes. Nuclear export of pre-ribosomal particles is one central step which also serves as an internal structural checkpoint to ensure the proper completion of nuclear assembly events. Here we present four structures of human pre-60S particles isolated through a nuclear export factor NMD3, representing assembly stages immediately before and after nuclear export. These structure ...[more]

PMID: 32669547

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