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Proteomic and Metabolomic Characterization of COVID-19 Patient Sera MRMHR

ABSTRACT: Targeted mass spectrometric assays for the 22 proteins in a second test cohort containing 19 COVID-19 patients

ORGANISM(S): Homo Sapiens

SUBMITTER: Tiannan Guo

PROVIDER: PXD019232 | iProX | Sat May 16 00:00:00 BST 2020

REPOSITORIES: iProX

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Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.

Shen Bo B Yi Xiao X Sun Yaoting Y Bi Xiaojie X Du Juping J Zhang Chao C Quan Sheng S Zhang Fangfei F Sun Rui R Qian Liujia L Ge Weigang W Liu Wei W Liang Shuang S Chen Hao H Zhang Ying Y Li Jun J Xu Jiaqin J He Zebao Z Chen Baofu B Wang Jing J Yan Haixi H Zheng Yufen Y Wang Donglian D Zhu Jiansheng J Kong Ziqing Z Kang Zhouyang Z Liang Xiao X Ding Xuan X Ruan Guan G Xiang Nan N Cai Xue X Gao Huanhuan H Li Lu L Li Sainan S Xiao Qi Q Lu Tian T Zhu Yi Y Liu Huafen H Chen Haixiao H Guo Tiannan T

Cell 20200528 1

Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a training cohort of 18 non-severe and 13 severe patients. The model was validated using 10 independent patients, 7 of which were correctly classified. Targeted proteomics and metabolomics assays were employe ...[more]

PMID: 32492406

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