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Proteomic and phosphoproteomic maps of lung squamous cell carcinoma from Chinese patients

ABSTRACT: Lung cancer in Chinese patients has distinct genomic features and lung squamous cell carcinoma (LUSC) has limited biomarkers for targeted therapy even though a lot of progress has been made in genomics research. Systematical research on LUSC at protein level will be beneficial to improve precision medicine. In this study, the large scale proteomics and phosphoproteomics analysis on clinical Chinese LUSC patients were performed.

ORGANISM(S): Homo Sapiens

SUBMITTER: Minjia Tan

PROVIDER: PXD019234 | iProX | Sat May 16 00:00:00 BST 2020

REPOSITORIES: iProX

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Proteomic and Phosphoproteomic Maps of Lung Squamous Cell Carcinoma From Chinese Patients.

Pan Lulu L Wang Xijun X Yang Longhai L Zhao Lei L Zhai Linhui L Xu Junyu J Yang Yikun Y Mao Yousheng Y Cheng Shujun S Xiao Ting T Tan Minjia M

Frontiers in oncology 20200616

Lung squamous cell carcinoma (LUSC) is one of the leading causes of tumor-driven deaths in the world. To date, studies on the tumor heterogeneity of LUSC at genomic level have only revealed limited therapeutic benefits. Therefore, system-wide research of LUSC at proteomic level may further improve precision medicine strategies on individual demands. To this end, we performed proteomic and phosphoproteomic study for LUSC samples of 25 Chinese patients. From our results, two subgroups (Cluster I a ...[more]

PMID: 32612956

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