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Time- and dose-resolved proteome of PM2.5 exposure in rat model

ABSTRACT: this paper used Mass spectrometry, Fast-seq, and catTFRE to study the pattern of 6316 proteins as well as 387 Transcription factors associated with PM2.5 in both short-term and long-term rat injury models.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Chen Ding

PROVIDER: PXD019404 | iProX | Wed May 27 00:00:00 BST 2020

REPOSITORIES: iProX

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Time- and Dose-Resolved Proteome of PM2.5-Exposure-Induced Lung Injury and Repair in Rats.

Zhang Fan F Yang Bing B Wang Yunzhi Y Zhu Jiajun J Liu Jie J Yu Guoying G Qin Jun J Song Weimin W Ding Chen C

Journal of proteome research 20200622 8

In recent years, airborne fine particulate matter (PM2.5) is drawing more public attention due to its various physicochemical features and causing pathological harm, as proven by epidemiological and clinical studies. However, the mechanism of PM2.5-exposure-induced lung injury has not been fully characterized. Here, we established a PM2.5-induced rat injury model for both short-term and long-term exposures at different concentrations. We employed the Fast-seq tec ...[more]

PMID: 32519869

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