Liquid chromatography-mass spectrometry based tissue metabolic profiling reveals major metabolic pathway alterations and potential biomarkers of lung cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Cancer
SUBMITTER: 
Guowang Xu
PROVIDER: PXD019969 | iProX | Fri Jun 19 00:00:00 BST 2020
REPOSITORIES: iProX
Publications
Liquid Chromatography-Mass Spectrometry-Based Tissue Metabolic Profiling Reveals Major Metabolic Pathway Alterations and Potential Biomarkers of Lung Cancer.
You Lei L Fan Yingying Y Liu Xinyu X Shao Shujuan S Guo Lei L Noreldeen Hamada A A HAA Li Zaifang Z Ouyang Yang Y Li Enyou E Pan Xue X Liu Tianyang T Tian Xin X Ye Fei F Li Xiangnan X Xu Guowang G
Journal of proteome research 20200731 9
Unclarified molecular mechanism and lack of practical diagnosis biomarkers hinder the effective treatment of non-small-cell lung cancer. Herein, we performed liquid chromatography-mass spectrometry-based nontargeted metabolomics analysis in 131 patients with their lung tissue pairs to study the metabolic characteristics and disordered metabolic pathways in lung tumor. A total of 339 metabolites were identified in metabolic profiling. Also, 241 differential metabolites were found between lung car ...[more]
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