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Interactome and proteomic survey of PMBCs from COVID-19 patients

ABSTRACT: Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

ORGANISM(S): Homo Sapiens

SUBMITTER: Chao Peng

PROVIDER: PXD020067 | iProX | Sun Jun 28 00:00:00 BST 2020

REPOSITORIES: iProX

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Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

Li Jingjiao J Guo Mingquan M Tian Xiaoxu X Wang Xin X Yang Xing X Wu Ping P Liu Chengrong C Xiao Zixuan Z Qu Yafei Y Yin Yue Y Wang Chunxia C Zhang Yucai Y Zhu Zhaoqin Z Liu Zhenshan Z Peng Chao C Zhu Tongyu T Liang Qiming Q

Med (New York, N.Y.) 20200721 1

<h4>Background</h4>The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a global public health concern due to relatively easy person-to-person transmission and the current lack of effective antiviral therapy. However, the exact molecular mechanisms of SARS-CoV-2 pathogenesis remain largely unknown.<h4>Methods</h4>Genome-wide screening was used to establish intraviral and viral-host interactomes. Quantitative proteomics ...[more]

PMID: 32838362

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