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Quantitative Proteome of Infant Stenotic Ureters Reveals Extracellular Matrix Organization and Oxidative Stress Dysregulation Underlying Ureteropelvic Junction Obstruction

ABSTRACT: Ureteropelvic junction obstruction (UPJO) is the most frequent cause of congenital hydronephrosis in child. To better investigate the molecular mechanisms of this pathological process, we performed data independent acquisition-based proteomics to compare the stenotic ureter proteome of UPJO in infants with their own normal pre-stenotic segments.

ORGANISM(S): Homo Sapiens

SUBMITTER: Hongquan Geng

PROVIDER: PXD020116 | iProX | Mon Aug 17 00:00:00 BST 2020

REPOSITORIES: iProX

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Quantitative Proteome of Infant Stenotic Ureters Reveals Extracellular Matrix Organization and Oxidative Stress Dysregulation Underlying Ureteropelvic Junction Obstruction.

Li Yueyan Y Chen Zhoutong Z Zhang Junqi J Zhang Qimin Q He Lei L Xu Maosheng M Xu Guofeng G Geng Hongquan H Fang Xiaoliang X

Proteomics. Clinical applications 20201019 6

<h4>Purpose</h4>Ureteropelvic junction obstruction (UPJO) is the most frequent cause of congenital hydronephrosis in child. To better investigate the molecular mechanisms of this pathological process, the stenotic ureter proteome of UPJO in infants is compared with their own normal pre-stenotic segments.<h4>Experimental design</h4>Data independent acquisition-based proteomics are performed to compare proteome between pre-stenotic and stenotic ureter from nine UPJO infants. Gene ontology analysis ...[more]

PMID: 32969194

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