Quantitative Proteome of Infant Stenotic Ureters Reveals Extracellular Matrix Organization and Oxidative Stress Dysregulation Underlying Ureteropelvic Junction Obstruction

ABSTRACT: Ureteropelvic junction obstruction (UPJO) is the most frequent cause of congenital hydronephrosis in child. To better investigate the molecular mechanisms of this pathological process, we performed data independent acquisition-based proteomics to compare the stenotic ureter proteome of UPJO in infants with their own normal pre-stenotic segments.

ORGANISM(S): Homo Sapiens

SUBMITTER: Hongquan Geng  

PROVIDER: PXD020116 | iProX | Mon Aug 17 00:00:00 BST 2020

REPOSITORIES: iProX