Global changes of transcriptomes between 3-month-old and 1-year-old human right atria
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ABSTRACT: Previous study showed that there are more cell cycle active cardiomyocytes (CMs) in 3-month-old (3M) than1-year-old (1Y) human atria, and extracellular matrix (ECM) from mouse atria benefits neonatal CMs proliferation. We investigate the global changes of transcriptomes between 3M and 1Y human atria and whether ECM from 3M human atria improves myocardium infarct recovery. RNAseq results showed that the major changes between 3M and 1Y human atria were ECM. 3M –ECM increased CM cell cycle activities and rescue mouse heart from injury. We conclude that 3M-ECM hold a therapeutic effect on myocardium infarction.
ORGANISM(S): Homo Sapiens
SUBMITTER: Jinfen Liu
PROVIDER: PXD020148 | iProX | Thu Jul 02 00:00:00 BST 2020
REPOSITORIES: iProX
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