Quantitative proteomics combine with affinity MS revealed the molecular mechanism of ginsenoside anti-tumor effects

ABSTRACT: The Tandem Mass Tag (TMT) labeling quantitative proteomics technique acquired 55620 MS/MS spectra that identified 5499 proteins and 3045 modified proteins. Of these identified proteins, 224 differentially expressed proteins and modified proteins were significantly altered in non-small cell lung cancer cell lines. Bioinformatics tools for comprehensive analysis revealed that the Ras protein played a general regulatory role in many functional pathways and was probably the direct target protein of a compound in ginsenosides.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wang Zhihua  

PROVIDER: PXD020149 | iProX | Sun Feb 17 00:00:00 GMT 2019

REPOSITORIES: iProX