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Proteomics of esophageal squamous cell carcinoma

ABSTRACT: study the differentially expressed proteins in esophageal squamous cell carcinoma

ORGANISM(S): Homo Sapiens

SUBMITTER: Chao Luo

PROVIDER: PXD020230 | iProX | Mon Jul 06 00:00:00 BST 2020

REPOSITORIES: iProX

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LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.

Tao Mingyue M Luo Jing J Gu Tong T Yu Xiaojuan X Song Zhen Z Jun Yali Y Gu Hao H Han Kairong K Huang Xiujuan X Yu Weiyong W Sun Su'an S Zhang Zhengwei Z Liu Lu L Chen Xiaofei X Zhang Li L Luo Chao C Wang Qilong Q

Cell death & disease 20210913 9

Tumor cells require high levels of cholesterol for membrane biogenesis for rapid proliferation during development. Beyond the acquired cholesterol from low-density lipoprotein (LDL) taken up from circulation, tumor cells can also biosynthesize cholesterol. The molecular mechanism underlying cholesterol anabolism in esophageal squamous cell carcinoma (ESCC) and its effect on patient prognosis are unclear. Dysregulation of lipid metabolism is common in cancer. Lysophosphatidylcholine acyltransfera ...[more]

PMID: 34518524

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