Both wnt signaling and epidermal stem cell-derived exosomes are involved in epidermal development

ABSTRACT: Millions suffer from skin diseases. Functional epidermal stem cells are needed in skin therapy or drug screening in vitro. We obtained functional epidermal stem cells with intact stemness and cell junctions by treating them with wnt3a. Moreover, epidermal stem cell-derived exosomes were useful in epidermal development. Finally, functional epidermal 3D organoids with polarity were cultured using wnt3a and the supernatant derived from epidermal stem cells and fresh medium in a 1:1 ratio. These results provide novel directions for the improvement of skin organoids and their potential in clinical application.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ling Leng  

PROVIDER: PXD020351 | iProX | Tue Jul 14 00:00:00 BST 2020

REPOSITORIES: iProX