Dataset Information
Identification of Escherichia coli FH-binding proteins
Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia Coli Rs218
SUBMITTER: 
Jianjun Dai
PROVIDER: PXD020521 | iProX | Thu Jul 23 00:00:00 BST 2020
REPOSITORIES: iProX
Publications
Factor H Is Bound by Outer Membrane-Displayed Carbohydrate Metabolism Enzymes of Extraintestinal Pathogenic <i>Escherichia coli</i> and Contributes to Opsonophagocytosis Resistance in Bacteria.
Frontiers in cellular and infection microbiology 20210125
Extraintestinal pathogenic <i>Escherichia coli</i> (ExPEC) causes bloodstream infections in humans and animals. Complement escape is a prerequisite for bacteria to survive in the bloodstream. Factor H (FH) is an important regulatory protein of the complement system. In this study, ExPEC was found to bind FH from serum. However, the mechanisms of ExPEC binding to FH and then resistance to complement-mediated attacks remain unclear. Here, a method that combined desthiobiotin pull-down and liquid c ...[more]
