Proteomics quantitative analysis of lung tissues in silica-exposed rats
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus Norvegicus
SUBMITTER: 
Cunxiang Bo
PROVIDER: PXD020625 | iProX | Wed Jul 29 00:00:00 BST 2020
REPOSITORIES: iProX
Publications
Comparative proteomic analysis of silica-induced pulmonary fibrosis in rats based on tandem mass tag (TMT) quantitation technology.
Bo Cunxiang C Geng Xiao X Zhang Juan J Sai Linlin L Zhang Yu Y Yu Gongchang G Zhang Zhenling Z Liu Kai K Du Zhongjun Z Peng Cheng C Jia Qiang Q Shao Hua H
PloS one 20201029 10
Silicosis is a systemic disease characterized by chronic persistent inflammation and incurable pulmonary fibrosis with the underlying molecular mechanisms to be fully elucidated. In this study, we employed tandem mass tag (TMT) based on quantitative proteomics technology to detect differentially expressed proteins (DEPs) in lung tissues of silica-exposed rats. A total of 285 DEPs (145 upregulated and 140 downregulated) were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genom ...[more]
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