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Nano-HPLC-MS/MS analysis for proteins encoded by circRNA in myoblasts and myotubes

ABSTRACT: The MS/MS spectra were searched against a custom protein database from span back-splice junction circRNA open reading frame prediction.

ORGANISM(S): Gallus Gallus

SUBMITTER: Qinghua Nie

PROVIDER: PXD021030 | iProX | Fri Aug 21 00:00:00 BST 2020

REPOSITORIES: iProX

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Long noncoding RNA <i>SMUL</i> suppresses <i>SMURF2</i> production-mediated muscle atrophy via nonsense-mediated mRNA decay.

Cai Bolin B Li Zhenhui Z Ma Manting M Zhang Jing J Kong Shaofen S Abdalla Bahareldin Ali BA Xu Haiping H Jebessa Endashaw E Zhang Xiquan X Lawal Raman Akinyanju RA Nie Qinghua Q

Molecular therapy. Nucleic acids 20201210

As the world population grows, muscle atrophy leading to muscle wasting could become a bigger risk. Long noncoding RNAs (lncRNAs) are known to play important roles in muscle growth and muscle atrophy. Meanwhile, it has recently come to light that many putative small open reading frames (sORFs) are hidden in lncRNAs; however, their translational capabilities and functions remain unclear. In this study, we uncovered 104 myogenic-associated lncRNAs translated, in at least a small peptide, by integr ...[more]

PMID: 33510940

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