Isobaric tags for relative and absolute quantitation labeling coupled with 2D-LC MS/MS proteomics analysis of anterior insula in morphine induced place preference rats with high frequency deep brain stimulation intervention
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus Rattus
SUBMITTER: 
Wang Feng
PROVIDER: PXD021122 | iProX | Tue Aug 25 00:00:00 BST 2020
REPOSITORIES: iProX
Publications
Continuous High Frequency Deep Brain Stimulation of the Rat Anterior Insula Attenuates the Relapse Post Withdrawal and Strengthens the Extinction of Morphine Seeking.
Chang Haigang H Gao Caibin C Sun Kuisheng K Xiao Lifei L Li Xinxiao X Jiang Shucai S Zhu Changliang C Sun Tao T Jin Zhe Z Wang Feng F
Frontiers in psychiatry 20201014
Deep brain stimulation (DBS) modulates the neuronal activity in specific brain circuits and has been recently considered as a promising intervention for refractory addiction. The insula cortex is the hub of interoception and is known to be involved in different aspects of substance use disorder. In the present study, we investigate the effects of continuous high frequency DBS in the anterior insula (AI) on drug-seeking behaviors and examined the molecular mechanisms of DBS action in morphine-add ...[more]
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