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Protein identification of cytotoxins isolated from Malaysian Naja sumatrana and Thai Naja kaouthia

ABSTRACT: Identification of cytotoxins using nano-ESI-LCMS/MS

ORGANISM(S): Naja Sumatrana Naja Kaouthia

SUBMITTER: Choo Hock Tan

PROVIDER: PXD021350 | iProX | Tue Sep 08 00:00:00 BST 2020

REPOSITORIES: iProX

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Cytotoxicity of Snake Venoms and Cytotoxins From Two Southeast Asian Cobras (Naja sumatrana, Naja kaouthia): Exploration of Anticancer Potential, Selectivity, and Cell Death Mechanism.

Chong Ho Phin HP Tan Kae Yi KY Tan Choo Hock CH

Frontiers in molecular biosciences 20201111

Venoms of cobras (Naja spp.) contain high abundances of cytotoxins, which contribute to tissue necrosis in cobra envenomation. The tissue-necrotizing activity of cobra cytotoxins, nevertheless, indicates anticancer potentials. This study set to explore the anticancer properties of the venoms and cytotoxins from Naja sumatrana (equatorial spitting cobra) and Naja kaouthia (monocled cobra), two highly venomous species in Southeast Asia. The cytotoxicity, selectivity, and cell ...[more]

PMID: 33263003

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