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Proteomics of intestine in simulated microgravity rats

ABSTRACT: After 14 days simulated microgravity，rats jejunal mucosa was taken for proteomic study. A total of 1826 proteins were detected, and 335 differentially expressed proteins were detected, of which 190 were up-regulated and 145 were down-regulated.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Yujuan Li

PROVIDER: PXD021522 | iProX | Thu Sep 17 00:00:00 BST 2020

REPOSITORIES: iProX

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Investigation on Intestinal Proteins and Drug Metabolizing Enzymes in Simulated Microgravity Rats by a Proteomics Method.

Liu Huayan H Guo Jingjing J Li Yujuan Y Zhang Yushi Y Wang Jiaping J Gao Jianyi J Deng Yulin Y Li Yongzhi Y

Molecules (Basel, Switzerland) 20200924 19

The present study aimed to investigate the change of intestinal mucosa proteins, especially the alteration of intestinal drug metabolizing enzymes (IDMEs) following 14-day simulated microgravity. Morey-Holton tail-suspension analog was used to simulate microgravity. Intestinal mucosa proteins of rats were determined by label-free quantitative proteomic strategy. A total of 335 differentially expressed proteins (DEPs) were identified, 190 DEPs were upregulated, and 145 DEPs were downregulated. Ac ...[more]

PMID: 32987831

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