Proteome-wide Hyposuccinylation of Esophageal Squamous Cell Cancer to Promotion of Tumor Metabolism and Migration

ABSTRACT: We identify abnormal protein and post-translational modification (PTM) pathways, including significantly downregulated lysine succinylation sites in cancer cells. Focusing on hyposuccinylation, we reveal that this altered PTM was enriched on enzymes of metabolic pathways inextricably linked with cancer metabolism. Importantly, ESCC malignant behaviors such as cell migration are inhibited once the level of succinylation was restored in vitro or in vivo. This effect was further verified by mutations to disrupt succinylation sites in candidate proteins.

ORGANISM(S): Homo Sapiens

SUBMITTER: Kai Zhang  

PROVIDER: PXD021567 | iProX | Fri Sep 18 00:00:00 BST 2020

REPOSITORIES: iProX