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The TMT-based quantitative proteomics of 5×FAD_Usp25 knockout mouse

ABSTRACT: The TMT-based quantitative proteomic raw data of 6-month-old WT, 5×FAD, 5×FAD:Usp25 KO mouse cerebral cortex including hippcampus.

ORGANISM(S): Mus Musculus

SUBMITTER: Xin Wang

PROVIDER: PXD021637 | iProX | Tue Sep 22 00:00:00 BST 2020

REPOSITORIES: iProX

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Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25.

Zheng Qiuyang Q Li Guilin G Wang Shihua S Zhou Ying Y Liu Ke K Gao Yue Y Zhou Yulin Y Zheng Liangkai L Zhu Lin L Deng Qingfang Q Wu Meiling M Di Anjie A Zhang Lishan L Zhao Yingjun Y Zhang Hongfeng H Sun Hao H Dong Chen C Xu Huaxi H Wang Xin X

Science advances 20210101 1

Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer's disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in combined murine DS-AD models. Overexpression of <i>USP25</i>, a deubiquitinating enzyme encoded by chromosome 21, results in microglial activation and induces synaptic and cognitive deficits, whereas gen ...[more]

PMID: 33523861

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