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Proteomic landscape and clinical prognosis of Japanese encephalitis patients with cognitive impairment phenotype

ABSTRACT: Quantitative proteomics was used to find the protective effects of traditional Chinese medicine Epimedium, Salvia miltiorrhiza, and Dioscorea nipponica Makino against osteoarthritis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Pengcheng Fan

PROVIDER: PXD021697 | iProX | Fri Sep 25 00:00:00 BST 2020

REPOSITORIES: iProX

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Proteomic landscape subtype and clinical prognosis of patients with the cognitive impairment by Japanese encephalitis infection.

Yin Rong R Yang Linpeng L Hao Ying Y Yang Zhiqi Z Lu Tao T Jin Wanjun W Dan Meiling M Peng Liang L Zhang Yingjie Y Wei Yaxuan Y Li Rong R Ma Huiping H Shi Yuanyuan Y Fan Pengcheng P

Journal of neuroinflammation 20220404 1

<h4>Background</h4>Cognitive impairment is one of the primary sequelae affecting the quality of life of patients with Japanese encephalitis (JE). The clinical treatment is mainly focused on life support, lacking of targeted treatment strategy.<h4>Methods</h4>A cerebrospinal fluid (CSF) proteomic profiling study was performed including 26 patients with JE in Gansu province of China from June 2017 to October 2018 and 33 other concurrent hospitalized patients who were excluded central nervous syste ...[more]

PMID: 35379280

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Proteomic landscape subtype and clinical prognosis of patients with the cognitive impairment by Japanese encephalitis infection.

Project description:BackgroundCognitive impairment is one of the primary sequelae affecting the quality of life of patients with Japanese encephalitis (JE). The clinical treatment is mainly focused on life support, lacking of targeted treatment strategy.MethodsA cerebrospinal fluid (CSF) proteomic profiling study was performed including 26 patients with JE in Gansu province of China from June 2017 to October 2018 and 33 other concurrent hospitalized patients who were excluded central nervous system (CNS) organic or CNS infection diseases. The clinical and proteomics data of patients with JE were undergoing combined analysis for the first time.ResultsTwo subtypes of JE associated with significantly different prognoses were identified. Compared to JE1, the JE2 subtype is associated with lower overall survival rate and a higher risk of cognitive impairment. The percentages of neutrophils (N%), lymphocyte (L%), and monocytes (M%) decreased in JE2 significantly.ConclusionsThe differences in proteomic landscape between JE subgroups have specificity for the prognosis of cognitive impairment. The data also provided some potential target proteins for treatment of cognitive impairments caused by JE. Trial registration ChiCTR, ChiCTR2000030499. Registered 1st June 2017, http://www.medresman.org.cn/pub/cn/proj/projectshow.aspx?proj=6333.

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