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Cerebrospinal Fluid Proteomics of Rats with Depression

ABSTRACT: Based on the proteomics of cerebrospinal fluid, this study aimed to explore the mechanism of depression and antidepressants..

ORGANISM(S): Rattus Rattus

SUBMITTER: Can Yan

PROVIDER: PXD021776 | iProX | Wed Sep 30 00:00:00 BST 2020

REPOSITORIES: iProX

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Cerebrospinal fluid proteomics reveal potential protein targets of JiaWeiSiNiSan in preventing chronic psychological stress damage.

Wang Han-Zhang HZ Luo Wu-Long WL Zeng Ning-Xi NX Li Hui-Zhen HZ Li Ling L Yan Can C Wu Li-Li LL

Pharmaceutical biology 20211201 1

<h4>Context</h4>Chinese herbal formula JiaWeiSiNiSan (JWSNS) has been widely used to prevent stress-induced neuropsychiatric ailments in clinics and proven to have therapeutic anti-stress effects on rats. However, the mechanism remains unclear.<h4>Objective</h4>Based on the proteomics of cerebrospinal fluid (CSF), this study explores the possible mechanism and target proteins of JiaWeiSiNiSan raising stress resilience and preventing stress damage.<h4>Materials and methods</h4>A 6-week Chronic Un ...[more]

PMID: 34383630

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