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Identification of proteins affected by PTENα under stress conditions by mass spectrometry

ABSTRACT: Stress granules are known to be related with selective translation. To determine which proteins are regulated by stress granules assembly in Ptenα─/─ MEFs, we performed a mass spectrometry analysis of Ptenα+/+ and Ptenα─/─ MEFs under oxidative stress.

ORGANISM(S): Mus Musculus

SUBMITTER: Yuxin Yin

PROVIDER: PXD021840 | iProX | Sat Oct 03 00:00:00 BST 2020

REPOSITORIES: iProX

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PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.

Sun Yizhe Y Lu Dan D Yin Yue Y Song Jia J Liu Yang Y Hao Wenyan W Qi Fang F Zhang Guangze G Zhang Xin X Liu Liang L Lin Zhiqiang Z Liang Hui H Zhao Xuyang X Jin Yan Y Yin Yuxin Y

Nature communications 20210826 1

PTEN is frequently mutated in human cancers and PTEN mutants promote tumor progression and metastasis. PTEN mutations have been implicated in immune regulation, however, the underlying mechanism is largely unknown. Here, we report that PTENα, the isoform of PTEN, remains active in cancer bearing stop-gained PTEN mutations. Through counteraction of CD8<sup>+</sup> T cell-mediated cytotoxicity, PTENα leads to T cell dysfunction and accelerates immune-resistant cancer progression. Clinical analysis ...[more]

PMID: 34446716

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