Mass spectrometry of human A549 cells transfected with EBV BRLF1
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Ersheng Kuang
PROVIDER: PXD021958 | iProX | Tue Oct 13 00:00:00 BST 2020
REPOSITORIES: iProX
Publications
BRLF1 suppresses RNA Pol III-mediated RIG-I inflammasome activation in the early EBV lytic lifecycle.
Long Xubing X Yang Jing J Zhang Xiaolin X Yang Ziwei Z Li Yang Y Wang Fan F Li Xiaojuan X Kuang Ersheng E
EMBO reports 20201123 1
Latent infection with herpesviruses constitutively activates inflammasomes, while lytic replication suppresses their activation through distinct mechanisms. However, how Epstein-Barr virus (EBV) lytic replication inhibits the activation of inflammasomes remains unknown. Here, we reveal that the EBV immediate-early protein BRLF1 inhibits inflammasome activation, and BRLF1 deficiency significantly increases the activation of inflammasomes and pyroptosis during early lytic lifecycle. BRLF1 interact ...[more]
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