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Hypothalamic proteomics of CMS-treated rats

ABSTRACT: We used a chronic mild stress (CMS) protocol to separate susceptible-depression, susceptible-anxiety and insusceptible rat subgroups. Differential proteomes in the hypothalamic were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrometry.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jian Zhou

PROVIDER: PXD022715 | iProX | Sat Nov 21 00:00:00 GMT 2020

REPOSITORIES: iProX

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Analysis of Chronic Mild Stress-Induced Hypothalamic Proteome: Identification of Protein Dysregulations Associated With Vulnerability and Resiliency to Depression or Anxiety.

Gong Weibo W Liao Wei W Fang Chui C Liu Yanchen Y Xie Hong H Yi Faping F Huang Rongzhong R Wang Lixiang L Zhou Jian J

Frontiers in molecular neuroscience 20210302

Chronic stress as a known risk factor leads to hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis in both depression and anxiety. However, the stress-induced dysfunction of the HPA axis in these disorders especially the common and unique molecular dysregulations have not been well-explored. Previously, we utilized a chronic mild stress (CMS) paradigm to segregate and gain depression-susceptible, anxiety-susceptible, and insusceptible groups. In this study, we continue to examine the ...[more]

PMID: 33737865

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