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Mapping novel biomarkers of liver injury by tissue proteomic analysis

ABSTRACT: Liver damage is a dynamic process and evaluation of liver injury degree is the key step in disease diagnose. However, few common markers between different types of liver injury have been reported. Herein, we generate three liver injury mouse models including Con A induced, CCl4 injected and subjected BDL mouse model to simulate different types of liver damage in humans and then perform a Label free mass spectrometry to identify differently expressed proteins in liver tissues. Interestingly, two proteins, G3BP and ABCC6, are proposed to be biomarkers in liver injury. Overall, our study identifies two novel biomarkers of liver injury and they might be used as potential drug targets of liver damage researches.

ORGANISM(S): Mus Musculus

SUBMITTER: Lei Li

PROVIDER: PXD022716 | iProX | Wed Nov 25 00:00:00 GMT 2020

REPOSITORIES: iProX

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Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis.

Yang Bo B Zhang Jianan J Sun Le L Huang Tingmei T Kong Yaqi Y Li Lei L Sun Zhengwang Z Yin Mengchen M Li Xiaotao X

ACS omega 20210302 10

Liver damage is a dynamic process, and evaluation of liver injury degree is the key step in disease diagnosis. However, few common markers among different types of liver injury have been reported. Herein, we generated three liver injury mouse models, including Con A-induced, CCl<sub>4</sub>-injected, and subjected bile duct ligation mouse models, to simulate different types of liver damage in humans and then performed a label-free mass spectrometry to identify differentially expressed proteins i ...[more]

PMID: 33748626

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