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Proteomic Analysis of Inactivated and Sterilized Sera might be Applied to Monitoring the Disease Course of COVID-19

ABSTRACT: We analyzed the proteome of 320 inactivated and sterilized sera from COVID-19 patients and controls.

ORGANISM(S): Homo Sapiens

SUBMITTER: Tiannan Guo

PROVIDER: PXD022751 | iProX | Thu Nov 19 00:00:00 GMT 2020

REPOSITORIES: iProX

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Potential Use of Serum Proteomics for Monitoring COVID-19 Progression to Complement RT-PCR Detection.

Zhang Ying Y Cai Xue X Ge Weigang W Wang Donglian D Zhu Guangjun G Qian Liujia L Xiang Nan N Yue Liang L Liang Shuang S Zhang Fangfei F Wang Jing J Zhou Kai K Zheng Yufen Y Lin Minjie M Sun Tong T Lu Ruyue R Zhang Chao C Xu Luang L Sun Yaoting Y Zhou Xiaoxu X Yu Jing J Lyu Mengge M Shen Bo B Zhu Hongguo H Xu Jiaqin J Zhu Yi Y Guo Tiannan T

Journal of proteome research 20211116 1

RT-PCR is the primary method to diagnose COVID-19 and is also used to monitor the disease course. This approach, however, suffers from false negatives due to RNA instability and poses a high risk to medical practitioners. Here, we investigated the potential of using serum proteomics to predict viral nucleic acid positivity during COVID-19. We analyzed the proteome of 275 inactivated serum samples from 54 out of 144 COVID-19 patients and shortlisted 42 regulated proteins in the severe group and 1 ...[more]

PMID: 34783559

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