Proteome-wide identification lncRNA CCAT1 directly binding proteins by RAP-MS

ABSTRACT: We purify and identify CCAT1 binding proteins by RAP-MS. As a result, we identified out more than 600 CCAT1 binding proteins and more than 60% of them are RNA binding proteins recorded by RBPs database EuRBPDB. Among the identified CCAT1 binding proteins, Vimentin is a crucial protein. Additionally, CCAT1 could positively influence the protein level of Vimentin and enhance migration and invasion ability of cancer cells. Our data indicate that CCAT1 may bind and stabilize Vimentin enhancing the migration and invasion ability of cancer Cell.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jikui Liu  

PROVIDER: PXD022774 | iProX | Thu Nov 26 00:00:00 GMT 2020

REPOSITORIES: iProX