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Raw data of 218 FFPE tissue proteomes containing 144 tissue samples from seven organs of fatal VID-19 cases and 74 control specimens from 56 non-COVID-19 individuals

ABSTRACT: 144 tissue samples from postmortem lung, liver, kidney, heart, spleen, testis and thyroid collected from 19 COVID-19 cases and 74 control specimens from 56 non-COVID-19 individuals were analyzed by PCT and TMT 16-plex based proteomics.

ORGANISM(S): Homo Sapiens

SUBMITTER: Tiannan GUo

PROVIDER: PXD022775 | iProX | Fri Dec 11 00:00:00 GMT 2020

REPOSITORIES: iProX

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Multi-organ proteomic landscape of COVID-19 autopsies.

Nie Xiu X Qian Liujia L Sun Rui R Huang Bo B Dong Xiaochuan X Xiao Qi Q Zhang Qiushi Q Lu Tian T Yue Liang L Chen Shuo S Li Xiang X Sun Yaoting Y Li Lu L Xu Luang L Li Yan Y Yang Ming M Xue Zhangzhi Z Liang Shuang S Ding Xuan X Yuan Chunhui C Peng Li L Liu Wei W Yi Xiao X Lyu Mengge M Xiao Guixiang G Xu Xia X Ge Weigang W He Jiale J Fan Jun J Wu Junhua J Luo Meng M Chang Xiaona X Pan Huaxiong H Cai Xue X Zhou Junjie J Yu Jing J Gao Huanhuan H Xie Mingxing M Wang Sihua S Ruan Guan G Chen Hao H Su Hua H Mei Heng H Luo Danju D Zhao Dashi D Xu Fei F Li Yan Y Zhu Yi Y Xia Jiahong J Hu Yu Y Guo Tiannan T

Cell 20210109 3

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5,336 were perturbed in the COVID-19 patients compared to controls. Our data showed that cathepsin L1, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Systemic hyperin ...[more]

PMID: 33503446

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