The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Fuping You
PROVIDER: PXD023002 | iProX | Tue Dec 08 00:00:00 GMT 2020
REPOSITORIES: iProX
Publications
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling.
Li Siji S Kuang Ming M Chen Luoying L Li Yunfei Y Liu Shengde S Du Hongqiang H Cao Lili L You Fuping F
Cell reports 20210101 3
Mitochondria not only serve as a platform for innate immune signaling transduction but also enhance immune responses by releasing mitochondrial DNA and RNA into the cytoplasm. However, whether mitochondrial matrix proteins could be liberated and involved in immune responses remains enigmatic. Here, we identify the mitochondrial protein ERA G-protein-like 1 (ERAL1) as a mitochondrial antiviral signaling protein (MAVS)-interacting protein by using proximity-based labeling technology. ERAL1 deficie ...[more]
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