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OVX-induced proteomic profile& HPL therapy

ABSTRACT: The original proteomic data for OVX-induced kidney dysfunction and hypericum perforatum L. (HPL) therapy actions exploring

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Yan-Ru Liu

PROVIDER: PXD023104 | iProX | Sun Dec 13 00:00:00 GMT 2020

REPOSITORIES: iProX

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ER-depletion lowering the 'hypothalamus-uterus-kidney' axis functions by perturbing the renal ERβ/Ptgds signalling pathway.

Liu Yan-Ru YR Tang Zhi-Shu ZS Duan Jin-Ao JA Chen Lin L Sun Jing J Zhou Rui R Song Zhong-Xing ZX Shi Xin-Bo XB Zhu Hui-Yuan HY

Aging 20191110 21

Researchers have long assumed that systematic estrogen fading might contribute to the sustained progression of menopausal degenerate syndromes, although definitive evidence has not been presented. Whether such findings represent a causal contribution or are the result of opportunistic messengers sent from the reproductive system to the brain is also a vital question. We constructed a multiscale network of the ovariectomy (OVX) induced estrogen receptors depletion (ER-depletion) model and integra ...[more]

PMID: 31708494

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