Proteomics

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An ITRAQ-Based Quantitative Proteomics Analysis of the Hepatoprotective Effect of Melatonin on ANIT-Induced Cholestasis in Rats.

ABSTRACT: The aim of the present study was to investigate the therapeutic mechanism of the anti-cholestatic effects of melatonin against ANIT-induced liver injury in rats, and to screen for potential biomarkers of cholestasis through isobaric tags for relative and absolute quantitation (iTRAQ) quantitative proteomics.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Xianggen Zhong  

PROVIDER: PXD023155 | iProX | Wed Dec 16 00:00:00 GMT 2020

REPOSITORIES: iProX

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iTRAQ-based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT-induced cholestasis in rats.

Wang Dingnan D   Yu Han H   Li Yunzhou Y   Xu Zongying Z   Shi Shaohua S   Dou Dou D   Sun Lili L   Zheng Zhili Z   Shi Xinghua X   Deng Xiulan X   Zhong Xianggen X  

Experimental and therapeutic medicine 20210715 3

The therapeutic effects of melatonin on cholestatic liver injury have received widespread attention recently. The aim of the present study was to investigate the mechanisms of the anti-cholestatic effects of melatonin against α-naphthyl isothiocyanate (ANIT)-induced liver injury in rats and to screen for potential biomarkers of cholestasis through isobaric tags for relative and absolute quantitation (iTRAQ) proteomics. Rats orally received melatonin (100 mg/kg body weight) or an equivalent volum  ...[more]

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