Proteomics

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ITRAQ-based proteomic analysis of the regulation for fengycin production by PhoPR two-component system in Bacillus subtilis strain NCD-2


ABSTRACT: The PhoPR two-component system regulated fengycin production by regulating the biosynthesis of branched amino acids in Bacillus subtilis strain NCD-2

ORGANISM(S): Halobacterium Salinarum

SUBMITTER: Ping Ma  

PROVIDER: PXD023319 | iProX | Fri Dec 25 00:00:00 GMT 2020

REPOSITORIES: iProX

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iTRAQ-based proteomic analysis of Bacillus subtilis strain NCD-2 regulated by PhoPR two-component system: A comparative analysis with transcriptomics revealed the regulation for fengycin production by branched chain amino acids.

Fu Yifan Y   Guo Qinggang Q   Dong Lihong L   Liu Xiaomeng X   Chen Xiuye X   Wang Peipei P   Su Zhenhe Z   Ma Ping P  

Microbiological research 20220416


The PhoPR two-component system (TCS) is a signal transduction pathway to regulate the phosphate starvation response in Bacillus subtilis and regulated fengycin production in strain NCD-2 under low phosphate condition. The purpose of this study was to characterize the proteome level responses in the phoP-null mutant (MP) and the phoR-null mutant (MR), and to integrate the proteomics with the transcriptomic data obtained previously. The metabolic pathway for fengycin was predicted based on omics a  ...[more]

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