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CD34 is a drug target for AML and CML

ABSTRACT: EGFR inhibitors selectively kill CD34+ leukemia cells and induced clinical remission in patients with high percentage of CD34+ blast

ORGANISM(S): Homo Sapiens

SUBMITTER: Ying Lu

PROVIDER: PXD023328 | iProX | Wed Dec 30 00:00:00 GMT 2020

REPOSITORIES: iProX

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Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells.

Xia Li L Liu Jie-Yang JY Yang Meng-Ying MY Zhang Xue-Hong XH Jiang Yue Y Yin Qian-Qian QQ Luo Chen-Hui CH Liu Hong-Chen HC Kang Zhi-Jie ZJ Zhang Cheng-Tao CT Gao Bei-Bei BB Zhou Ai-Wu AW Cai Hai-Yan HY Waller Edmund K EK Yan Jin-Song JS Lu Ying Y

Cancer research 20240201 3

Osimertinib is a third-generation covalent EGFR inhibitor that is used in treating non-small cell lung cancer. First-generation EGFR inhibitors were found to elicit pro-differentiation effect on acute myeloid leukemia (AML) cells in preclinical studies, but clinical trials yielded mostly negative results. Here, we report that osimertinib selectively induced apoptosis of CD34+ leukemia stem/progenitor cells but not CD34- cells in EGFR-negative AML and chronic myeloid leukemia (CML). Covalent bind ...[more]

PMID: 38095536

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