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Retinal conditional knockout EMC3 in mice

ABSTRACT: Control and EMC3 CKO retinas (n = 3 each group) at E17.5 and P7 were used for tandem mass spectrometry (LC-MS/MS)–based label-free proteomics

ORGANISM(S): Mus Musculus

SUBMITTER: Xiangtian Zhou

PROVIDER: PXD023349 | iProX | Mon Jan 04 00:00:00 GMT 2021

REPOSITORIES: iProX

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EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development.

Cao Xiaowen X An Jianhong J Cao Yuqing Y Lv Juan J Wang Jiawei J Ding Yang Y Lin Xinhua X Zhou Xiangtian X

Investigative ophthalmology & visual science 20210201 2

<h4>Purpose</h4>We used a mouse model to explore the role of the endoplasmic reticulum membrane protein complex subunit 3 (EMC3) in mammalian retinal development.<h4>Methods</h4>The transcription pattern of Emc3 in C57BL/6 mice was analyzed by in situ hybridization. To explore the effects of EMC3 absence on retinal development, the Cre-loxP system was used to generate retina-specific Emc3 in knockout mice (Emc3flox/flox, Six3-cre+; CKO). Morphological changes in the retina of E13.5, E17.5, P0.5, ...[more]

PMID: 33605987

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