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TMT-based proteomic approach was used to compare the liver protein expression profiles of cancer cachexia mice and healthy control mice

ABSTRACT: TMT-based proteomic approach was used to compare the liver protein expression profiles of cancer cachexia mice and healthy control mice.

ORGANISM(S): Mus Musculus

SUBMITTER: Xiongwen Zhang

PROVIDER: PXD023497 | iProX | Mon Jan 11 00:00:00 GMT 2021

REPOSITORIES: iProX

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Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome.

Feng Lixing L Zhang Wanli W Shen Qiang Q Miao Chunxiao C Chen Lijuan L Li Yiwei Y Gu Xiaofan X Fan Meng M Ma Yushui Y Ma Yushui Y Wang Hui H Liu Xuan X Zhang Xiongwen X

Journal of cachexia, sarcopenia and muscle 20210928 6

<h4>Background</h4>Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA) metabolism might be involved. The aim of the present study was to clarify the contribution of liver and gut microbiota to BA metabolism disturbance in cancer cachexia and to check the possibility of targeting BA metabolism using agents such as tauroursodeoxycholic acid (TUDCA) for cancer cachexia therapy.<h4>Methods</h4>The BA profiles in liver, intestine, and serum of mice with cancer cachexia indu ...[more]

PMID: 34585527

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