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Integrated tissue proteome and metabolome reveal key elements and regulatory pathways in cutaneous squamous cell carcinoma

ABSTRACT: we took advantage of nanoscale liquid chromatography and quadrupole time-of-flight tandem mass spectrometry (nanoLC/Q-TOF-MS/MS) and ultraperformance LC/Q-TOF-MS/MS techniques on cancer and the corresponding paracancerous tissues from 20 CSCC patients for integrated proteomic and metabolomic analyses

ORGANISM(S): Homo Sapiens

SUBMITTER: Jun Rao

PROVIDER: PXD023716 | iProX | Wed Jan 20 00:00:00 GMT 2021

REPOSITORIES: iProX

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Integrated tissue proteome and metabolome reveal key elements and regulatory pathways in cutaneous squamous cell carcinoma.

Chen Wen W Rao Jun J Liu Zhiwen Z You Xiaolong X Yuan Fenqian F Le Fei F Tang Mu M Zhou Meng M Xie Ting T

Journal of proteomics 20210706

Cutaneous squamous cell carcinoma (CSCC) is a widespread malignancy but has a very low long-term survival rate for patients at the metastatic stage. Therefore, it is urgent to identify prognostic biomarkers for CSCC and improve our understanding of disease progression. Here we took advantage of a data-independent acquisition (DIA)-based nano liquid chromatography equipped with an orbitrap mass spectrometry (nLC-MS/MS) and ultraperformance LC coupled to a time-of-flight tandem MS (UPLC-TOF-MS/MS) ...[more]

PMID: 34237460

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