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Olfactory bulb proteomics of CMS-treated rats

ABSTRACT: We used a chronic mild stress (CMS) protocol to separate susceptible-depression, susceptible-anxiety and insusceptible rat subgroups. Differential proteomes in the olfactory bulb were analyzed based on isobaric tags for relative and absolute quantitation (iTRAQ) labeling combined with mass spectrometry.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jian Zhou

PROVIDER: PXD023766 | iProX | Mon Apr 12 00:00:00 BST 2021

REPOSITORIES: iProX

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Comparative Proteomics of Rat Olfactory Bulb Reveal Insights into Susceptibility and Resiliency to Chronic-stress-induced Depression or Anxiety.

Liu Dan D Cai Xiao X Wang Lixiang L Yi Faping F Liao Wei W Huang Rongzhong R Fang Chui C Chen Jin J Zhou Jian J

Neuroscience 20210821

Chronic stress causes the abnormality of olfactory bulb (OB) in both anxiety and depression, however, the unique and common neurobiological underpinnings are still poorly understood. Previously, we built the three groups by chronic mild stress (CMS), depression-susceptible (Dep-Sus): with depression-like behavior, anxiety-susceptible (Anx-Sus): with anxiety-like behavior and insusceptible (Insus): without depression- and anxiety-like behaviors. To continuously explore the protein expression chan ...[more]

PMID: 34425157

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