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Proteins in the kidney of mice infected by Babesia microti

ABSTRACT: The dynamic changes of all proteins in the kidney of mice infected with Babesia were studied by using dia quantitative proteomics technology, and the regulation strategy of proteins in the kidney of mice infected with Babesia was discussed.

ORGANISM(S): Mus Musculus

SUBMITTER: Hui Wang

PROVIDER: PXD023863 | iProX | Wed Jan 27 00:00:00 GMT 2021

REPOSITORIES: iProX

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The regulatory strategy of proteins in the mouse kidney during Babesia microti infection.

Li Mengxue M Yang Xiaohong X Masoudi Abolfazl A Xiao Qi Q Li Ning N Wang Ningmei N Chang Guomin G Ren Shuguang S Li Hongxia H Liu Jingze J Wang Hui H

Experimental parasitology 20220225

Babesia is a protozoan that mainly parasitizes mammalian red blood cells. It causes damage to multiple organs of the host, even threatening the life of the host when the infection is severe. This study found that the mouse kidney was injured after Babesia infection, leading to changes such as ischaemia and an abnormal morphology of renal and epithelial cells. Serum tests showed that indices reflecting renal abnormalities (including serum creatinine, uric acid, and bilirubin) appeared to be abnor ...[more]

PMID: 35227683

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