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Identification of replication and transcription machinery for cross species infectious ranaviruses

ABSTRACT: Ranaviruses are promiscuous pathogens that can infect across species barriers in aquatic animals. Here, a complicated replication and transcription machinery were screened and uncovered from the two ranavirus infected lower vertebrate cells by isolation of proteins on nascent DNA, recombinant virus-based affinity, and Mass spectrometry.

ORGANISM(S): Rana Grylio Virus 9506 Andrias Davidianus Ranavirus Andrias Davidianus

SUBMITTER: Qiya Zhang

PROVIDER: PXD024049 | iProX | Sun Feb 07 00:00:00 GMT 2021

REPOSITORIES: iProX

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Replication and transcription machinery for ranaviruses: components, correlation, and functional architecture.

Ke Fei F Yu Xue-Dong XD Wang Zi-Hao ZH Gui Jian-Fang JF Zhang Qi-Ya QY

Cell & bioscience 20220106 1

<h4>Background</h4>Ranaviruses (family Iridoviridae) are promiscuous pathogens that can infect across species barriers in poikilotherms and can replicate in amphibian and fish cells and even in cultured mammalian cells. However, as nucleocytoplasmic large DNA viruses (NCLDVs), their replication and transcription mechanisms remain largely unknown. Here, we screened and uncovered the replication and transcription machinery of two ranaviruses, Andrias davidianus ranavirus (ADRV) and Rana grylio vir ...[more]

PMID: 34991685

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