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EIF4E2 regulates GSK3b kinase activity

ABSTRACT: we found eIF4E2 regulates GSK3b kinase activity. And we performed the quantitative iTRAQ-based phosphoproteomic to identify phophosites regulated by eIF4E2-GSK3b pathway

ORGANISM(S): Homo Sapiens

SUBMITTER: Min Zhang

PROVIDER: PXD024226 | iProX | Wed Feb 17 00:00:00 GMT 2021

REPOSITORIES: iProX

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Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia.

Sun Lei L Yang He H He Dong D Chen Jian J Dong Zhiqiang Z Luo Shaoxiang S Liang Huiting H Cao Yu Y Cai Bingcheng B Zhang Min M

Cell death & disease 20220514 5

Hypoxia modulates senescence, but their physiological link remains unclear. Here, we found that eIF4E2, a hypoxia-activated translation initiation factor, interacted with GSK3β to maintain phosphorylation of p53, thus resisting senescence under hypoxia. RNA-binding protein RBM38 interacted with eIF4E to inhibit the translation of p53, but GSK3β-mediated Ser195 phosphorylation disrupted the RBM38-eIF4E interaction. Through investigation of RBM38 phosphorylation, we found that the eIF4E2-GSK3β pat ...[more]

PMID: 35568694

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