Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Ting Wang
PROVIDER: PXD024228 | iProX | Thu Feb 18 00:00:00 GMT 2021
REPOSITORIES: iProX
Shang Man M Yang Huijie H Yang Ran R Chen Tao T Fu Yuan Y Li Yeyi Y Fang Xianlong X Zhang Kangjian K Zhang Jianju J Li Hui H Cao Xueping X Gu Jinfa J Xiao Jianwen J Zhang Qi Q Liu Xinyuan X Yu Qiujing Q Wang Ting T
Nature communications 20210329 1
Metabolic enzymes and metabolites display non-metabolic functions in immune cell signalling that modulate immune attack ability. However, whether and how a tumour's metabolic remodelling contributes to its immune resistance remain to be clarified. Here we perform a functional screen of metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2). Mechanistically, MTH ...[more]