Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Chen Ding
PROVIDER: PXD024255 | iProX | Fri Sep 09 00:00:00 BST 2022
REPOSITORIES: iProX
Li Yan Y Xu Chen C Wang Bing B Xu Fujiang F Ma Fahan F Qu Yuanyuan Y Jiang Dongxian D Li Kai K Feng Jinwen J Tian Sha S Wu Xiaohui X Wang Yunzhi Y Liu Yang Y Qin Zhaoyu Z Liu Yalan Y Qin Jing J Song Qi Q Zhang Xiaolei X Sujie Akesu A Huang Jie J Liu Tianshu T Shen Kuntang K Zhao Jian-Yuan JY Hou Yingyong Y Ding Chen C
Nature communications 20220929 1
Chemotherapy and targeted therapy are the major treatments for gastric cancer (GC), but drug resistance limits its effectiveness. Here, we profile the proteome of 206 tumor tissues from patients with GC undergoing either chemotherapy or anti-HER2-based therapy. Proteome-based classification reveals four subtypes (G-I-G-IV) related to different clinical and molecular features. MSI-sig high GC patients benefit from docetaxel combination treatment, accompanied by anticancer immune response. Further ...[more]