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Proteins that interact with FGD5 in MDA-MB-231

ABSTRACT: To examine the presence of the proteins that interact with FGD5 in triple negative breast cancer cell line

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhuo-Wei Hu

PROVIDER: PXD024266 | iProX | Fri Feb 19 00:00:00 GMT 2021

REPOSITORIES: iProX

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Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

Li Ke K Zhang Ting-Ting TT Zhao Chen-Xi CX Wang Feng F Cui Bing B Yang Zhao-Na ZN Lv Xiao-Xi XX Yeerjiang Zaiwuli Z Yuan Yu-Fen YF Yu Jin-Mei JM Wang Zhen-He ZH Zhang Xiao-Wei XW Yu Jiao-Jiao JJ Liu Shan-Shan SS Shang Shuang S Huang Bo B Hua Fang F Hu Zhuo-Wei ZW

Science translational medicine 20210301 586

Most basal-like breast cancers (BLBCs) are triple-negative breast cancers (TNBCs), which have the worst prognosis and distant metastasis-free survival among breast cancer subtypes. Now, no targeted therapies are available for patients with BLBC due to the lack of reliable and effective molecular targets. Here, we performed the BLBC tissue microarray-based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 (FGD5) abundance is associated with poor prognosis in BLBCs. <i>FGD5</i> ...[more]

PMID: 33762435

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