ARIH1 Signaling Promotes Anti-tumor Immunity by Targeting PD-L1 for Proteasomal Degradation

ABSTRACT: We find EGFR inhibitors promote PD-L1 ubiquitination and proteasomal degradation following GSK3α-mediated phosphorylation of Ser279/Ser283.

ORGANISM(S): Homo Sapiens

SUBMITTER: Hongguang Xia  

PROVIDER: PXD024452 | iProX | Mon Mar 01 00:00:00 GMT 2021

REPOSITORIES: iProX