Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

ABSTRACT: Here we apply integrated epigenomic and transcriptomic profiling to uncover super-enhancer heterogeneity between breast cancer subtypes, and provide clinically relevant biological insights towards TNBC. Using CRISPR/Cas9-mediated gene editing, we identify genes that are specifically regulated by TNBC-specific super-enhancers, including FOXC1 and MET, thereby unveiling a mechanism for specific overexpression of the key oncogenes in TNBC. We also identify ANLN as a novel TNBC-specific gene regulated by super-enhancer. Our studies reveal a TNBC-specific epigenomic landscape, contributing to the dysregulated oncogene expression in breast tumorigenesis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Liang Zhang  

PROVIDER: PXD024505 | iProX | Thu Mar 04 00:00:00 GMT 2021

REPOSITORIES: iProX