Discovery of a cooperative mode of inhibiting RIPK1 kinase

ABSTRACT: By using Limited Proteolysis-Mass Spectrometry (LiP-MS) and Hydrogen Deuterium Exchange-Mass Spectrometry (HDX-MS) analysis, we identified the binding pocket of Nec-34 in RIPK1 kinase domain. This newly identified binding pocket of Nec-34 is distinct from distinct from that of Nec-1s.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ying Li  

PROVIDER: PXD024560 | iProX | Sun Mar 07 00:00:00 GMT 2021

REPOSITORIES: iProX