Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Zhigang Hu
PROVIDER: PXD024595 | iProX | Tue Mar 09 00:00:00 GMT 2021
REPOSITORIES: iProX
Zhang Ziyu Z Zhou Qian Q Liu Rui R Liu Li L Shen Wen-Jun WJ Azhar Salman S Qu Yan-Fu YF Guo Zhigang Z Hu Zhigang Z
The Journal of biological chemistry 20210101
The scavenger receptor class B type 1 (SR-B1), a high-density lipoprotein (HDL) receptor, is a membrane glycoprotein that mediates selective uptake of HDL-cholesterol and cholesterol ester (CE) into cells. SR-B1 is subject to posttranslational regulation; however, the underlying mechanisms still remain obscure. Here, we identified a novel SR-B1-interacting protein, GIPC1 (GAIP-interacting protein, C terminus 1) that interacts with SR-B1 and stabilizes SR-B1 by negative regulation of its proteaso ...[more]