Proteomics

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A global multi-regional proteomic map of the human cerebral cortex

ABSTRACT: In this study, four groups of the iTRAQ quantification experiment using 2D-LC-MS/MS analysis, one group of the label-free quantification experiment using 2D-LC-MS/MS analysis, one group of the PRM quantification experiment of the human brain tissue were included. Therefore, six subprojects are included in this project. Subproject IPX0001938001 is composed of the label-free analysis of Brodmann Area 46 sub-dataset generated by In-solution Digestion and High-pH RPLC Separation (20 Fractions). Subproject IPX0001938003 is composed of the iTRAQ analysis of 29 Brodmann Areas (group 1) sub-dataset generated by In-solution Digestion and High-pH RPLC Separation (20 Fractions). Subproject IPX0001938004 is composed of the iTRAQ analysis of 29 Brodmann Areas (group 2) sub-dataset generated by In-solution Digestion and High-pH RPLC Separation (20 Fractions). Subproject IPX0001938005 is composed of the iTRAQ analysis of 29 Brodmann Areas (group 3) sub-dataset generated by In-solution Digestion and High-pH RPLC Separation (20 Fractions). Subproject IPX0001938006 is composed of the iTRAQ analysis of 29 Brodmann Areas (group 4) sub-dataset generated by In-solution Digestion and High-pH RPLC Separation (20 Fractions). Subproject IPX0001938007 is composed of the PRM analysis of 27 Brodmann Areas sub-dataset generated by In-solution Digestion.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wei Sun  

PROVIDER: PXD024613 | iProX | Tue Mar 09 00:00:00 GMT 2021

REPOSITORIES: iProX

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A Global Multiregional Proteomic Map of the Human Cerebral Cortex.

Guo Zhengguang Z   Shao Chen C   Zhang Yang Y   Qiu Wenying W   Li Wenting W   Zhu Weimin W   Yang Qian Q   Huang Yin Y   Pan Lili L   Dong Yuepan Y   Sun Haidan H   Xiao Xiaoping X   Sun Wei W   Ma Chao C   Zhang Liwei L  

Genomics, proteomics & bioinformatics 20211108 4

The Brodmann area (BA)-based map is one of the most widely used cortical maps for studies of human brain functions and in clinical practice; however, the molecular architecture of BAs remains unknown. The present study provided a global multiregional proteomic map of the human cerebral cortex by analyzing 29 BAs. These 29 BAs were grouped into 6 clusters based on similarities in proteomic patterns: the motor and sensory cluster, vision cluster, auditory and Broca's area cluster, Wernicke's area  ...[more]

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