Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Alexander Strunnikov
PROVIDER: PXD024713 | iProX | Fri Mar 12 00:00:00 GMT 2021
REPOSITORIES: iProX
Boukaba Abdelhalim A Liu Jian J Ward Carl C Wu Qiongfang Q Arnaoutov Alexei A Liang Jierong J Pugacheva Elena M EM Dasso Mary M Lobanenkov Victor V Esteban Miguel M Strunnikov Alexander V AV
Proceedings of the National Academy of Sciences of the United States of America 20220930 40
Many tumors express meiotic genes that could potentially drive somatic chromosome instability. While germline cohesin subunits SMC1B, STAG3, and REC8 are widely expressed in many cancers, messenger RNA and protein for RAD21L subunit are expressed at very low levels. To elucidate the potential of meiotic cohesins to contribute to genome instability, their expression was investigated in human cell lines, predominately in DLD-1. While the induction of the REC8 complex resulted in a mild mitotic phe ...[more]